Structure of PDB 5umd Chain L Binding Site BS02

Receptor Information
>5umd Chain L (length=211) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VAHNNVLPNVHLHKWWQHRVRVNFSKNIKKKKRRLLREKRRKANGGTPIE
KLHPIVHCPTQRYNFRTRLGKGFTFEELKGAGLTPRAAQTIGICYDKRRK
NRSEESLTKNVERLLKYKNSLVMIPLKKNKAKKGIGGIPADADKNTIKEF
RNKKPLLSIFKKEKNTKPFYETIEVSKIDKEFLAYKTLRRAKLAERRKNC
RQQKKDIKFKS
Ligand information
>5umd Chain C (length=151) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agcacagucuuaacgauggaugucuugguuccuacagcgaugaaggccgc
agcaaaaugcgauacgcaaugaaaauugcagugacugaaucaucagaaug
cugaauguaaacuacaccaauucccugggaauagugguacuccuacagaa
a
............................................<<<<<<
.((.....>>>.....<.<<<<..<<.)).>>.......>>>>..>...>
>>....<<.....>><<<<<<<<<<.>>>>>>..>>>>............
.
Receptor-Ligand Complex Structure
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PDB5umd Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		F25 S26 I29
Binding residue
(residue number reindexed from 1)		F24 S25 I28
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5umd, PDBe:5umd, PDBj:5umd
PDBsum5umd
PubMed28288098
UniProtQ8IAX6

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