Structure of PDB 4xlr Chain L Binding Site BS02

Receptor Information
>4xlr Chain L (length=345) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DPVRQYLHEIGQVPLLTLEEEIDLARKVEEGMEAIKKLSEATGLDQELIR
EVVRAKILGTARIQKIPGLKEKPDPKTVEEVDGKLKSLPKELKRYLHIAR
EGEAARQHLIEANLRLVVSIAKKYTGRGLSFLDLIQEGNQGLIRAVEKFE
YKRRFKFSTYATWWIRQAINRAIADQARTIRIPVHMVETINKLSRTARQL
QQELGREPSYEEIAEAMGPGWDAKRVEETLKIAQEPVSLETPIGDEKDSF
YGDFIPDENLPSPVEAAAQSLLSEELEKALSKLSEREAMVLKLRKGLIDG
REHTLEEVGAYFGVTRERIRQIENKALRKLKYHESRTRKLRDFLE
Ligand information
>4xlr Chain S (length=48) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcatccgtgagtcgagggtaataagcacaatttaacacttttgtcaag
Receptor-Ligand Complex Structure
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PDB4xlr CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex.
Resolution4.3 Å
Binding residue
(original residue number in PDB)		R220 N263 N284 S287 R288 R291 Q327 E339 S342 F347 R387 T397 L398 R409 E410 R413
Binding residue
(residue number reindexed from 1)		R127 N170 N191 S194 R195 R198 Q234 E246 S249 F254 R294 T304 L305 R316 E317 R320
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0016987 sigma factor activity
Biological Process
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:4xlr, PDBe:4xlr, PDBj:4xlr
PDBsum4xlr
PubMed26349034
UniProtQ9EZJ8|SIGA_THEAQ RNA polymerase sigma factor SigA (Gene Name=sigA)

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