Structure of PDB 2c4r Chain L Binding Site BS02

Receptor Information
>2c4r Chain L (length=491) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AHIEGRHMKRMLINATQQEELRVALVDGQRLYDLDIESPGHEQKKANIYK
GKITRIEPSLEAAFVDYGAERHGFLPLKEIAREYFPNIKDVLREGQEVIV
QIDKEERGNKGAALTTFISLAGSYLVLMPNNPRAGGISRRIELKEALASL
ELPEGMGLIVRTAGVGKSAEALQWDLSFRLKHWEAIKKAAESRPAPFLIH
QESNVIVRAFRDYLRQDIGEILIDNPKVLELARQHIAALGRPDFSSKIKL
YTGEIPLFSHYQIESQIESAFQREVRLPSGGSIVIDSTEALTAIDINSAR
GDIEETAFNTNLEAADEIARQLRLRDLGGLIVIDFIDMTPVRHQRAVENR
LREAVRQDRARIQISHISRFGLLEMSRQRLSPSLGESSHHVCPRCSGTGT
VRDNESLSLSILRLIEEEALKENTQEVHAIVPVPIASYLLNEKRSAVNAI
ETRQDGVRCVIVPNDQMETPHYHVLRVRKGEETPTLSYMLP
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain2c4r Chain L Residue 1511 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2c4r Structure of E. Coli Rnase E Catalytic Domain and Implications for RNA Processing and Turnover
Resolution3.6 Å
Binding residue
(original residue number in PDB)		D303 D346
Binding residue
(residue number reindexed from 1)		D295 D334
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.26.12: ribonuclease E.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004540 RNA nuclease activity
GO:0008995 ribonuclease E activity
Biological Process
GO:0006396 RNA processing

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2c4r, PDBe:2c4r, PDBj:2c4r
PDBsum2c4r
PubMed16237448
UniProtP21513|RNE_ECOLI Ribonuclease E (Gene Name=rne)

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