Structure of PDB 8qbk Chain K Binding Site BS02

Receptor Information
>8qbk Chain K (length=309) Species: 469008 (Escherichia coli BL21(DE3)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SAEYLNTFRLRNLGLPVMNNLHDMSKATRISVETLRLLIYTADFRYRIYT
VEKKGPEKRMRTIYQPSRELKALQGWVLRNILDKLSSSPFSIGFEKHQSI
LNNATPHIGANFILNIDLEDFFPSLTANKVFGVFHSLGYNRLISSVLTKI
CCYKNLLPQGAPSSPKLANLICSKLDYRIQGYAGSRGLIYTRYADDLTLS
AQSMKKVVKARDFLFSIIPSEGLVINSKKTCISGPRSQRKVTGLVISQEK
VGIGREKYKEIRAKIHHIFCGKSSEIEHVRGWLSFILSVDSKSHRRLITY
ISKLEKKYG
Ligand information
>8qbk Chain M (length=61) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ugcgcacccuuagcgagaggccucuggauguugcggcauccugcauugaa
ucugaguuacu
...............<<<<..>>>><<<<<<<..>>>>>>>.........
...........
Receptor-Ligand Complex Structure
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PDB8qbk Retron-Eco1 assembles NAD + -hydrolyzing filaments that provide immunity against bacteriophages.
Resolution2.99 Å
Binding residue
(original residue number in PDB)		K56 R63 I65 K73 R81 F96 E97 H99 Q100 A163 P164 P167 K230 C233 P237 R238 S239 Q240 S249 K252 R257 K261 R264 A265 G283 S286 S290 R298
Binding residue
(residue number reindexed from 1)		K54 R61 I63 K71 R79 F94 E95 H97 Q98 A161 P162 P165 K228 C231 P235 R236 S237 Q238 S247 K250 R255 K259 R262 A263 G281 S284 S288 R296
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006974 DNA damage response
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:8qbk, PDBe:8qbk, PDBj:8qbk
PDBsum8qbk
PubMed38788717
UniProtP23070|RT86_ECOLX Retron Ec86 reverse transcriptase (Gene Name=ret)

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