Structure of PDB 8ihl Chain K Binding Site BS02

Receptor Information

>8ihl Chain K (length=73) Species: 9606 (Homo sapiens)

LIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLC
AIHAKRVTIMPKDIQLARRIRGE

Ligand information

>8ihl Chain J (length=353)

atcggatgtatatatctgacacgtgcctggagactagggagtaatcccct
tggcggttaaaacgcgggggacagcgcgtacgtgcgtttaagcggtgcta
gagctgtctacgaccaattgagctcgagcctggagactagggagtaatcc
ccttggcggttaaaacgcgggggacagcgcgtacgtgcgtttaagcggtg
ctagagctgtctacgaccaattgagctcgagcctggagactagggagtaa
tccccttggcggttaaaacgcgggggacagcgcgtacgtgcgtttaagcg
gtgctagagctgtctacgaccaattgagcggcctcggcaccgggattctc
gat

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ihl Genome-wide mapping and cryo-EM structural analyses of the overlapping tri-nucleosome composed of hexasome-hexasome-octasome moieties.
• Resolution: 7.64 Å
• Binding residue (original residue number in PDB): R63 R72 R83 F84 R116 V117 T118 M120
• Binding residue (residue number reindexed from 1): R3 R12 R23 F24 R56 V57 T58 M60

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005515 protein binding
• GO:0030527 structural constituent of chromatin
• GO:0045296 cadherin binding
• GO:0046982 protein heterodimerization activity

Biological Process

• GO:0006325 chromatin organization
• GO:0006334 nucleosome assembly
• GO:0010467 gene expression
• GO:0032200 telomere organization
• GO:0040029 epigenetic regulation of gene expression

Cellular Component

• GO:0000786 nucleosome
• GO:0005576 extracellular region
• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005694 chromosome
• GO:0016020 membrane
• GO:0032991 protein-containing complex
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:8ihl, PDBe:8ihl, PDBj:8ihl
• PDBsum: 8ihl
• PubMed: 38191828
• UniProt: P68431|H31_HUMAN Histone H3.1 (Gene Name=H3C1)