Structure of PDB 8i0p Chain K Binding Site BS02

Receptor Information
>8i0p Chain K (length=312) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LTPKAIANRIKSKGLQKLRWYCQMCQKQCRDENGFKCHCMSESHQRQLLL
ASENPQQFMDYFSEEFRNDFLELLRRRFGTKRVHNNIVYNEYISHREHIH
MNATQWETLTDFTKWLGREGLCKVDETPKGWYIQYIDRDPETIRRQLELE
KKKKQDLDDEEKTAKFIEEQVRRGLEGSALDEIMEIEEEKKRTARTDYWL
QPEIIVKIITKKLGEKYHKKKAIVKEVIDKYTAVVKMIDSGDKLKLDQTH
LETVIPAPGKRILVLNGGYRGNEGTLESINEKTFSATIVIETGPLKGRRV
EGIQYEDISKLA
Ligand information
>8i0p Chain G (length=63) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cuccgaacgguaagagccuagcauguagaaugaugucauacuuauccugu
cccuuuuuuuucc
..................................................
.............
Receptor-Ligand Complex Structure
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PDB8i0p Molecular Basis for the activation of Human spliceosome
Resolution3.4 Å
Binding residue
(original residue number in PDB)		L21 Q22 K23 N92 Y95 N96 T114
Binding residue
(residue number reindexed from 1)		L15 Q16 K17 N86 Y89 N90 T108
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006397 mRNA processing
GO:0006974 DNA damage response
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016363 nuclear matrix
GO:0032991 protein-containing complex
GO:0043231 intracellular membrane-bounded organelle

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Biological Process
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Cellular Component
External links
PDB RCSB:8i0p, PDBe:8i0p, PDBj:8i0p
PDBsum8i0p
PubMed39068178
UniProtO60870|KIN17_HUMAN DNA/RNA-binding protein KIN17 (Gene Name=KIN)

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