Structure of PDB 8ham Chain K Binding Site BS02

Receptor Information
>8ham Chain K (length=517) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PEELRQALMPTLEALYRQDPESLPFRQPVDPIPDYFDIVKNPMDLSTIKR
KLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEID
PVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKC
FTEISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVC
DNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVF
VRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVC
FFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYL
EYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLD
KAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKDLSQ
KLYATMEKHKEVFFVIHLHDPDPLLSCDLMDGRDAFLTLARDKHWEFSSL
RRSKWSTLCMLVELHTQ
Ligand information
>8ham Chain J (length=165) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ccgttaccgccatcaatatccacctgcagattctaccaaaagtgtatttg
gaaactgctccatcaaaaggcatgttcagctgaattcagctgaacatgcc
ttttgatggagcagtttccaaatacacttttggtagaatctgcaggtgga
tattgatggcggtaa
Receptor-Ligand Complex Structure
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PDB8ham Epigenetic mechanisms to propagate histone acetylation by p300/CBP.
Resolution4.5 Å
Binding residue
(original residue number in PDB)		R1169 T1171 R1173 R1443 K1505 F1523 K1524
Binding residue
(residue number reindexed from 1)		R79 T81 R83 R335 K397 F415 K416
Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:8ham, PDBe:8ham, PDBj:8ham
PDBsum8ham
PubMed37460559
UniProtQ92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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