Structure of PDB 8hal Chain K Binding Site BS02

Receptor Information

>8hal Chain K (length=513) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDL
STIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVF
EQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQHFCE
KCFTEKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVC
DNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVF
VRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVC
FFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYL
EYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLD
KAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKEKLY
ATMEKHKEVFFVIHLHLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWST
LCMLVELHTQGQD

Ligand information

>8hal Chain J (length=151) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gccatcaatatccacctgcagattctaccaaaagtgtatttggaaactgc
tccatcaaaaggcatgttcagctgaattcagctgaacatgccttttgatg
gagcagtttccaaatacacttttggtagaatctgcaggtggatattgatg
g

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8hal Epigenetic mechanisms to propagate histone acetylation by p300/CBP.
Resolution	4.4 Å
Binding residue (original residue number in PDB)	R1169 K1170
Binding residue (residue number reindexed from 1)	R84 K85

Enzymatic activity

Enzyme Commision number

2.3.1.-
2.3.1.48: histone acetyltransferase.

Gene Ontology

	Molecular Function
GO:0004402	histone acetyltransferase activity
GO:0008270	zinc ion binding

	Biological Process
GO:0006355	regulation of DNA-templated transcription

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Molecular Function

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Biological Process

External links

PDB	RCSB:8hal, PDBe:8hal, PDBj:8hal
PDBsum	8hal
PubMed	37460559
UniProt	Q92793\|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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