Structure of PDB 8haj Chain K Binding Site BS02

Receptor Information
>8haj Chain K (length=533) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSPMDL
STIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVF
EQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQNRYH
FCEKCFNEIQGESNKEQFSKRKNDTLDPELFVECTECGRKMHQICVLHHE
IIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQ
NHPESGEVTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAF
EEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAV
YHEILIGYLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRL
QEWYKKMLDKAVSERIVHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVL
EESIKENDLSQKLYATMEKHKEVFFVIRLIIVDPDPLIPCDLMDGRDAFL
TLARDKHLEFSSLRRAQWSTMCMLVELHTQSQD
Ligand information
>8haj Chain J (length=162) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgttaccgccatcaatatccacctgcagattctaccaaaagtgtatttgg
aaactgctccatcaaaaggcatgttcagctgaattcagctgaacatgcct
tttgatggagcagtttccaaatacacttttggtagaatctgcaggtggat
attgatggcggt
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8haj Epigenetic mechanisms to propagate histone acetylation by p300/CBP.
Resolution4.8 Å
Binding residue
(original residue number in PDB)		R1133 R1137 F1487 E1589 K1592
Binding residue
(residue number reindexed from 1)		R84 R88 F424 E468 K471
Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8haj, PDBe:8haj, PDBj:8haj
PDBsum8haj
PubMed37460559
UniProtQ09472|EP300_HUMAN Histone acetyltransferase p300 (Gene Name=EP300)

[Back to BioLiP]