Structure of PDB 7uv9 Chain K Binding Site BS02

Receptor Information
>7uv9 Chain K (length=407) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RYSQRLRRRYRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDP
LIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQ
WTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPR
HLKESQTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIH
QGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYT
FVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFR
YPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDLEQVHLTHFELEG
LRCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLALTG
VPIVQWP
Ligand information
Ligand IDFE
InChIInChI=1S/Fe/q+3
InChIKeyVTLYFUHAOXGGBS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Fe+3]
FormulaFe
NameFE (III) ION
ChEMBL
DrugBankDB13949
ZINC
PDB chain7uv9 Chain K Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7uv9 Structural basis of paralog-specific KDM2A/B nucleosome recognition.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		H212 D214 H284
Binding residue
(residue number reindexed from 1)		H187 D189 H259
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.11.27: [histone H3]-dimethyl-L-lysine(36) demethylase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:7uv9, PDBe:7uv9, PDBj:7uv9
PDBsum7uv9
PubMed36797403
UniProtQ9Y2K7|KDM2A_HUMAN Lysine-specific demethylase 2A (Gene Name=KDM2A)

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