Structure of PDB 7u46 Chain K Binding Site BS02

Receptor Information
>7u46 Chain K (length=205) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQ
HLIHLCEEKRASISDAALLDIIYMQFHQHQKVWDVFQMSKGFDMKQFKNS
FKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQ
TPYAFTSSSMLRRNTPLLGQALTIASKHHQIVKMDLRSRYLDSLKAIVFK
QYNQT
Ligand information
>7u46 Chain J (length=145) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tcaatatccacctgcagatactaccaaaagtgtatttggaaactgctcca
tcaaaaggcatgttcagctggattccagctgaacatgccttttgatggag
cagtttccaaatacacttttggtagtatctgcaggtggatattga
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7u46 CENP-N promotes the compaction of centromeric chromatin.
Resolution2.68 Å
Binding residue
(original residue number in PDB)		P17 K45 K148 M167 R169 R170
Binding residue
(residue number reindexed from 1)		P17 K45 K141 M160 R162 R163
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0007059 chromosome segregation
GO:0034080 CENP-A containing chromatin assembly

View graph for
Biological Process
External links
PDB RCSB:7u46, PDBe:7u46, PDBj:7u46
PDBsum7u46
PubMed35422519
UniProtQ96H22|CENPN_HUMAN Centromere protein N (Gene Name=CENPN)

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