Structure of PDB 7enn Chain K Binding Site BS02

Receptor Information
>7enn Chain K (length=539) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AARVQEQDLRQWGLTGIHLRSYQLEGVNWLAQRFHCQNGCILGDEMGLGK
TCQTIALFIYLAGRLNDEGPFLILCPLSVLSNWKEEMQRFAPGLSCVTYA
GDKEERACLQQDLKQESRFHVLLTTYEICLKDASFLKSFPWSVLVVDEAH
RLKNQSSLLHKTLSEFSVVFSLLLTGTPIQNSLQELYSLLSFVEPDLFSK
EEVGDFIQRYQDIEKESESASELHKLLQPFLLRRVKAEVATELPKKTEVV
IYHGMSALQKKYYKAILMKKLQNILSQLRKCVDHPYLFDGVEPEPFEVGD
HLTEASGKLHLLDKLLAFLYSGGHRVLLFSQMTQMLDILQDYMDYRGYSY
ERVDGSVRGEERHLAIKNFGQQPIFVFLLSTRAGGVGMNLTAADTVIFVD
SDFNPQNDLQAAARAHRIGQNKSVKVIRLIGRDTVEEIVYRKAASKLQLT
NMIIEGGHFEILKFGLDKLLASEGSTMDEIDLESILGETKDGQWVSDAEG
KNHMYLFEGKDYSKEPSKEDRKSFEQLVNLQGRSLRNKG
Ligand information
>7enn Chain J (length=146) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tcaggatgtatatatctgacacgtgcctggagactagggagtaatcccct
tggcggttaaaacgcgggggacagcgcgtacgtgcgtttaagcggtgcta
gagctgtctacgaccaattgagcggcctcggcaccgggattctcca
Receptor-Ligand Complex Structure
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PDB7enn Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		R133 E154 K310 Q312 K320 M372 T373 D394 R402 S420 R422 A423
Binding residue
(residue number reindexed from 1)		R106 E127 K270 Q272 K280 M332 T333 D354 R362 S380 R382 A383
Enzymatic activity
Enzyme Commision number 3.6.4.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003678 DNA helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0031491 nucleosome binding
GO:0140566 histone reader activity
GO:0140658 ATP-dependent chromatin remodeler activity
GO:0160004 poly-ADP-D-ribose modification-dependent protein binding
Biological Process
GO:0006281 DNA repair
GO:0006338 chromatin remodeling
GO:0006974 DNA damage response
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0035861 site of double-strand break

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7enn, PDBe:7enn, PDBj:7enn
PDBsum7enn
PubMed34210977
UniProtQ86WJ1|CHD1L_HUMAN Chromodomain-helicase-DNA-binding protein 1-like (Gene Name=CHD1L)

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