Structure of PDB 7aav Chain K Binding Site BS02

Receptor Information
>7aav Chain K (length=123) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELR
ANGKVITNKAVKGKYKFLQKYYHRGAFFMDEDEEVYKRDFSAPTLEDHFN
KTILPKVMQVKNFGRSGRTKYTH
Ligand information
>7aav Chain 5 (length=69) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuucc
guggagaggaacaacucug
...<<<<<<<<<<........<<<<<<<<.<.......>.>>>>>>>>..
.>>>>>>>>>>........
Receptor-Ligand Complex Structure
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PDB7aav Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		F383 R385 S386 R388
Binding residue
(residue number reindexed from 1)		F113 R115 S116 R118
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0001527 microfibril
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005813 centrosome
GO:0071005 U2-type precatalytic spliceosome

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Cellular Component
External links
PDB RCSB:7aav, PDBe:7aav, PDBj:7aav
PDBsum7aav
PubMed33243851
UniProtP55081|MFAP1_HUMAN Microfibrillar-associated protein 1 (Gene Name=MFAP1)

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