Structure of PDB 6pwv Chain K Binding Site BS02

Receptor Information
>6pwv Chain K (length=98) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQS
SAVMALQEASEAYLVALFEDTNLCAIHAKRVTIMPKDIQLARRIRGER
Ligand information
>6pwv Chain P (length=146) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atcggatgtatatatctgacacgtgcctggagactagggagtaatcccct
tggcggttaaaacgcgggggacagcgcgtacgtgcgtttaagcggtgcta
gagctgtctacgaccaattgagcggcctcggcaccgggattctcga
Receptor-Ligand Complex Structure
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PDB6pwv Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.
Resolution6.2 Å
Binding residue
(original residue number in PDB)		R40 Y41 P43 G44 T45 V46 A47 R49 K56 R63 K64 L65 P66 R69 R83
Binding residue
(residue number reindexed from 1)		R4 Y5 P7 G8 T9 V10 A11 R13 K20 R27 K28 L29 P30 R33 R47
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0046982 protein heterodimerization activity
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome

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Molecular Function
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Cellular Component
External links
PDB RCSB:6pwv, PDBe:6pwv, PDBj:6pwv
PDBsum6pwv
PubMed31804488
UniProtP84233|H32_XENLA Histone H3.2

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