Structure of PDB 6kiu Chain K Binding Site BS02

Receptor Information
>6kiu Chain K (length=179) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ARAEVHLRKSAFDMFNFLASKHRQARRATSMDLPMPMRFRHLKKTSKEAV
GVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIG
CYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAM
RKIYRGEELTYDYKLPCNCGAKKCRKFLN
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6kiu Chain K Residue 4002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6kiu Structural basis of nucleosome recognition and modification by MLL methyltransferases.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		C3957 C3959
Binding residue
(residue number reindexed from 1)		C167 C169
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.
External links
PDB RCSB:6kiu, PDBe:6kiu, PDBj:6kiu
PDBsum6kiu
PubMed31485071
UniProtQ03164|KMT2A_HUMAN Histone-lysine N-methyltransferase 2A (Gene Name=KMT2A)

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