Structure of PDB 3jcm Chain K Binding Site BS02

Receptor Information
>3jcm Chain K (length=279) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PNLELHEDKFLLDLSKFKIYYDNNHGYEWWDTAYLVAHPLPEKIIKAYLT
QHERKRLRRNRRKMAREAREIKIKLGLLPKPEPKVKLSNMMSVFENDQNI
TDPTAWEKVVKDQVDLRKRKHLEENERRHEDAIKRRKEAVNMNVEKPTVY
HCKVFQFKNLQNPKIRFKLKMNSKELSLKGLCLRIRDDGPGIIIVVGNEK
SCKFYENLVMKRIKWNEDFELHTNTGDIKMDMHNNSISKTWEGYLQDCKF
KGWFMKVCNDQDSLLRTLGQFDSEHFYSP
Ligand information
>3jcm Chain E (length=85) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auccuuaugcacgggaaauacgcauaucagugaggauucguccgagauug
uguuuuugcugguuagggaauuuuuggaauaccuu
...................<<<<<.<<<.....<<<....>>>..>>>>>
>>>................................
Receptor-Ligand Complex Structure
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PDB3jcm The 3.8 angstrom structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis
Resolution3.8 Å
Binding residue
(original residue number in PDB)		R241 R246 R249 K273 R304 H308 R315
Binding residue
(residue number reindexed from 1)		R54 R59 R62 K86 R117 H121 R128
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000387 spliceosomal snRNP assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005687 U4 snRNP
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071001 U4/U6 snRNP

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3jcm, PDBe:3jcm, PDBj:3jcm
PDBsum3jcm
PubMed26743623
UniProtQ03338|PRP3_YEAST U4/U6 small nuclear ribonucleoprotein PRP3 (Gene Name=PRP3)

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