Structure of PDB 1hlt Chain K Binding Site BS02

Receptor Information
>1hlt Chain K (length=251) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTG
QPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDS
GGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVID
Q
Ligand information
Receptor-Ligand Complex Structure
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PDB1hlt Structure of a nonadecapeptide of the fifth EGF domain of thrombomodulin complexed with thrombin.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		Q38 R67 Y76 R77A I82
Binding residue
(residue number reindexed from 1)		Q24 R62 Y71 R73 I78
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1hlt, PDBe:1hlt, PDBj:1hlt
PDBsum1hlt
PubMed7947765
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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