Structure of PDB 1de7 Chain K Binding Site BS02

Receptor Information
>1de7 Chain K (length=251) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
G
Ligand information
Receptor-Ligand Complex Structure
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PDB1de7 Interaction of the factor XIII activation peptide with alpha -thrombin. Crystal structure of its enzyme-substrate analog complex.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		H57 Y60A W60D R97 E97A R173 I174 D189 A190 C191 E192 S195 S214 W215 G216 E217
Binding residue
(residue number reindexed from 1)		H43 Y47 W50 R93 E94 R171 I172 D192 A193 C194 E195 S198 S219 W220 G221 E222
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1de7, PDBe:1de7, PDBj:1de7
PDBsum1de7
PubMed10956659
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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