Structure of PDB 7ajt Chain JN Binding Site BS02

Receptor Information

>7ajt Chain JN (length=186) Species: 559292 (Saccharomyces cerevisiae S288C)

KTQPKVIRGPSDVYVPPSKKTQKLLRSNLQNDLELQQFLRESHLLSAFNN
IVYQDDQVIGKARSRTLEMRLNRLSRVNGHQDKINKLEKVPMHIRRGMID
KHVKRIKKYEQEAAEGGIVLSKVKKGQFRKIESTYKKDIERRIGGSIKAR
DKEKATKRERGLKISSVGRSTRNGLIVSKRDIARIS

Ligand information

>7ajt Chain D3 (length=1327)

aagauaguuaucugguugauccugccagucauaugcuugucucaaagauu
aagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaaug
gcucauuaaaucaguuaucguuuauuugauagcaugguauaacuguggua
auucuagagcuaauacaugcuaucucgacccuuuggaagagauuauuuau
uagauucuucggacucuugaugauucauaauaacuuuucgaaucgcaugg
ccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgau
gguaggauaguggccuaccaugguuucaacggguaacggggaauaagggu
ucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggc
agcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaa
auaacgauacagggcccauucgggucuuguaauuggaaugaguacaaugu
aaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccg
cgguaauuccagcuccaauagcguauauugcucguaguugaacuuugggc
ccgguuggccggucggauuuccaacggggccuuuuuacuuugaaaaaauu
agaguguucaaagcaggcguauugcucgauauauuagcauggaauaauag
gacguuugguucuauuuuguugguuucuaggaccaucguaauuaauaggg
acggucgggggcaucaguauucaauugucagaggugaaauucuuggauuu
auugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaau
caagaacgaaacuaugccgacuagggaucgggugguguuuuuuuaaugac
ccacucggcaccuuacgaggaguauggucgcaaggcugaaacuuaaagga
auugacggaagggcaccaccaggaguggagccugcggaaacucaccaggu
ccagacacaauauuugugggugguggugcaugugaugcccuuguucuggc
gcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuu
gguaaaaacuccgucggggaacgaggaauuccuaguaagcgcaagucauc
agcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuag
uaccgauugaauggcuuagugaggccucaggaucugcuuagagaaggggg
caacuccaucucagagcggaaauuuggacaaacuuggucauuuagaggaa
cuaaguuuccguaggugaaccugcgga

...........................<<.<<<<<<...<.<........
..<<<.<<<..<<....<<....<<..........>>...>>.>>.....
.<<..<.....<<<..<<..<<....<<<.......<<....<<.<<<..
...>>>.>>.....>>.....<<<<<..<<....>>..>>>>>...<<<<
<<...<<....>>....<<......>>>>>>>>.........<<<<..<<
<.....>>>.>>>>....>>>...>>>>..>>>.<<<.....<......<
<<<<<<.......>>>>>>>..>.......>>>...<<<.<<<......>
>>....>>>>>>.<<.<<<<........>>>>.>>.<.<......>.>..
.>>>>>>.........<<<....<<<.....>>>..>>>.......>.>.
....<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<<..<....
.......>..>>.........<<<<<<.......<<<....>>>......
............>>>>>>..>>>>>>>>.<.<<...<<<.<<....<<<<
<<.<<<<<............>>>>>.>>>>>>..<<<<<.<<........
...<<.......>>..<<.....>>............>>.>>..>>>...
.<<<....<..<<...............>>..>...>>>..>>....<<<
<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.
>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>
...>>.>..........<<...<<<..<<<<<<<<.<<<........>>>
>>>>>>>>..>>>..>>..................<<.........>>..
...<<<<<<<<<<<<..<<.<<<<<...<<<.<<<<........<<<<<.
.....<<<<<...>>>>>......<<...........>>.....>>>>>>
>>>.>>>.....<<<<<<<............<<<..<<<<....>>>>..
>>>.....>>>>>>>.............>>>>>....<<<<<<<<.....
..>>>>>>>>......>>...>>>>>>>............>>>>>..<<<
<.<<....<<<<<<<<.<<...<.<<......<<<<<<<....<.<.<..
....>.>.>....>>>>>>>.....>>.>...>>.>>>>>>>>...>>.>
>>>....<<<<<<<<....>>>>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7ajt Structure of the Maturing 90S Pre-ribosome in Association with the RNA Exosome.
• Resolution: 4.6 Å
• Binding residue (original residue number in PDB): L231 M236 R239 K269 K292 R294 K298 K301 R302 R304 G305 K307 T315 R316
• Binding residue (residue number reindexed from 1): L87 M92 R95 K125 K148 R150 K154 K157 R158 R160 G161 K163 T171 R172

Gene Ontology

Molecular Function

• GO:0003674 molecular_function

Biological Process

• GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0042254 ribosome biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm

External links

• PDB: RCSB:7ajt, PDBe:7ajt, PDBj:7ajt
• PDBsum: 7ajt
• PubMed: 33326748
• UniProt: P40546|FAF1_YEAST Protein FAF1 (Gene Name=FAF1)