Structure of PDB 6gzz Chain J1 Binding Site BS02

Receptor Information
>6gzz Chain J1 (length=122) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIQPQTYLEVADNTGARKIMCIRVLKGSNAKYATVGDVIVASVKEAIPRG
AVKEGDVVKAVVVRTKKEIKRPDGSAIRFDDNAAVIINNQLEPRGTRVFG
PVARELREKGFMKIVSLAPEVL
Ligand information
>6gzz Chain A3 (length=1506) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagac
augcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacg
ggugaguaacgcgugggugaccuacccggaagagggggacaacccgggga
aacucgggcuaaucccccauguggacccgccccuugggguguguccaaag
ggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguugguggg
guaauggcccaccaaggcgacgacggguagccggucugagaggauggccg
gccacaggggcacugagacacgggccccacuccuacgggaggcagcaguu
aggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggag
gaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccga
cgaggggacugacgguaccgggguaauagcgccggccaacuccgugccag
cagccgcgguaauacggagggcgcgagcguuacccggauucacugggcgu
aaagggcguguaggcggccuggggcgucccaugugaaagaccacggcuca
accgugggggagcgugggauacgcucaggcuagacggugggagagggugg
uggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccg
auggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcg
uggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaug
cgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgc
gccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacggg
ggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaaga
accuuaccaggccuugacaugcuagggaacccgggugaaagccuggggug
ccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucg
ugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguu
aguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcg
ggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggc
gacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggg
gagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccg
accccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggu
gaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgg
gcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggc
ccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggc
uggauc
....<<<<....(((..>>>>.<<...<<<<...<<<<<<<......<<<
.<<<..<<<..<<...........................>>>>>.....
.<<.......<<<<<<<<..<<...<<<<<....<<<.....<<<<<...
...>>>>>......>>>.....<<<<.<<<<<....>>>>>.>>>>....
<......>.....>>>>>..>>>>>>>>>><<<.....<....<<<<<<<
.......>>>>>>>..>.......>>>..<<<<<<<<....>>>>...>>
>>.>>.<<<<<.<.........>>>>>>.<<........>>...>>>>>>
......<...<<....<<<<....>>>>..>>..>.>.>>>>>>..<<<<
......<<<......>>>.....>>>>...<<<<<<......<.<<<<..
...>>>>..>.......>>>>>.>....<<<<<(((...<<<<<.....<
..))).>.......>>>>>>>>>>...>>>>..>>..........<<<((
.....<<<<...<<<.<<<<....<<<<<<<<<<......<<<<<<....
.>>>>>>....>>>>>>>..>>>...>>>>....<...<<.....<<<<<
<....<<<<<<<....<<........>>.......>>>>>>>........
...<......>.>>>>>>...>>.....>....>>>...>>>>....<<<
<<<...<<...<<<<.........>>>>...>>>>>>>>..........<
<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>
>>.>>>.<<<......<<<<....>>>>....>>>...)))..<<<<<.<
<<<<<<....<<<<<<...<<<<<<<........<<........>>....
......<<<<.......................<........>.......
........................<.......<<<<<<<.......<<<<
<<<<....>>>..<<<<......>>>>..>>>>>......<<<<.<<<<<
<<...<..............>.....>>>>>>>.....<<<<<....>>>
>>........>>>>.......>.>>>...>>>.....>......>>.>>.
....>>>>>>>......<<<<.........<...<...<<<<....>>>>
...>.....>.........>>>>......<....<<<<<<<........>
>>>>>>....>.....>>>>>>.....<<<<<............>>>>>.
...........>>>>>>>>>>.>>....<..<<...<<<<.<<<..<<<<
<<<<<<<<<...<..<<.....<........>..>>..>..>>>>>>>>>
>>>>..>>>.>>>>....>>...>.....<<<<<<<<<....>>>>>>>>
>.....
Receptor-Ligand Complex Structure
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PDB6gzz Cryo-EM structure of the hibernating Thermus thermophilus 100S ribosome reveals a protein-mediated dimerization mechanism.
Resolution4.13 Å
Binding residue
(original residue number in PDB)		R17 P48 R49 R97 S116
Binding residue
(residue number reindexed from 1)		R17 P48 R49 R97 S116
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
GO:0070180 large ribosomal subunit rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6gzz, PDBe:6gzz, PDBj:6gzz
PDBsum6gzz
PubMed30301898
UniProtQ5SHP8|RL14_THET8 Large ribosomal subunit protein uL14 (Gene Name=rplN)

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