Structure of PDB 8q7n Chain J Binding Site BS02

Receptor Information
>8q7n Chain J (length=260) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PEIEWWDSYIIFGITNLVEHPAQLNPPDTPVTLGVYLTKKEQKKLRRQTR
REAQKELQEKVRLGLMPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQ
MAKRQKAHEEANAARKLTAEQRKVKKIKKLKEDISQGVHISVYRVRNLSN
PAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIK
WDETNKCVLVWEGTAKDRSFGEMKFKQCPTENMAREHFKKHGAEHYWDLA
LSESVLESTD
Ligand information
>8q7n Chain 4 (length=76) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agcuuugcgcaguggcaguaucguagccaaugagguuuauccgaggcgcg
auuauugcuaauacuuuucccaauac
...................<<<<<.<<<.....<<.....>>..>>>>>>
>>........................
Receptor-Ligand Complex Structure
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PDB8q7n New insights into the functions of B complex proteins revealed by cryo-EM of dimerized spliceosomes
Resolution3.1 Å
Binding residue
(original residue number in PDB)		K443 K447 R449 R450 Q461 R465 R477 R507 Q508 H511 R518 K526 K529
Binding residue
(residue number reindexed from 1)		K40 K44 R46 R47 Q58 R62 R74 R104 Q105 H108 R115 K123 K126
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005829 cytosol
GO:0015030 Cajal body
GO:0016607 nuclear speck
GO:0032991 protein-containing complex
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8q7n, PDBe:8q7n, PDBj:8q7n
PDBsum8q7n
PubMed38383864
UniProtO43395|PRPF3_HUMAN U4/U6 small nuclear ribonucleoprotein Prp3 (Gene Name=PRPF3)

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