Structure of PDB 8oz0 Chain J Binding Site BS02

Receptor Information
>8oz0 Chain J (length=687) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TKRVVRSAKDKRFEELTNLIRTIRNAMKIRDVTKCLEEFELLGKAYGKAK
SIVDKEGVPRFYIRILADLEDYLNELWEDKEGKKKMNKNNAKALSTLRQK
IRKYNRDFESAKGTEITHAVVIKKLNEILQARGKKGTDRAAQIELLQLLV
QIAAENNLGEGVIVKIKFNIIASLYDYNPNLATYMKPEMWGKCLDCINEL
MDILFANPNIFVGENILEESENLHNADQPLRVRGCILTLVERMDEEFTKI
MQNTDPHSQEYVEHLKDEAQVCAIIERVQRYLEEKGTTEEVCRIYLLRIL
HTYYKFDYKAHQRQLTPPEGSSKSEQDQAENEGEDSAVLMERLCKYIYAK
DRTDRIRTCAILCHIYHHALHSRWYQARDLMLMSHLQDNIQHADPPVQIL
YNRTMVQLGICAFRQGLTKDAHNALLDIQSSGRAKELLGQGLLLRSLQER
NQEQEKVERRRQVPFHLHINLELLECVYLVSAMLLEIPYMAAHESDARRR
MISKQFHHQLRVGERQPLLGPPESMREHVVAASKAMKMGDWKTCHSFIIN
EKMNGKVWDLFPEADKVRTMLVRKIQEESLRTYLFTYSSVYDSISMETLS
DMFELDLPTVHSIISKMIINEELMASLDQPTQTVVMHRTEPTAQQNLALQ
LAEKLGSLVENNERVFDHKQGTYGGYFRDQKDGYRKN
Ligand information
>8oz0 Chain z (length=50) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ccgcagucagauccuagcgucgaguugaugcuguccgauaaaaaaaaaaa
..................................................
Receptor-Ligand Complex Structure
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PDB8oz0 The structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		R653 K712 H716
Binding residue
(residue number reindexed from 1)		R445 K504 H508
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0031369 translation initiation factor binding
GO:0043022 ribosome binding
Biological Process
GO:0001732 formation of cytoplasmic translation initiation complex
GO:0002183 cytoplasmic translational initiation
GO:0006412 translation
GO:0006413 translational initiation
GO:0045727 positive regulation of translation
GO:1902416 positive regulation of mRNA binding
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0016282 eukaryotic 43S preinitiation complex
GO:0032991 protein-containing complex
GO:0033290 eukaryotic 48S preinitiation complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8oz0, PDBe:8oz0, PDBj:8oz0
PDBsum8oz0
PubMed38287194
UniProtQ99613|EIF3C_HUMAN Eukaryotic translation initiation factor 3 subunit C (Gene Name=EIF3C)

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