Structure of PDB 7xd9 Chain J Binding Site BS02

Receptor Information
>7xd9 Chain J (length=625) Species: 11060 (dengue virus type 2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQT
GSASSMVNGVVRLLTKPWDIIPMVTQMAMTDTTPFGQQRVFKEKVDTRTQ
EPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFT
DENKWKSAREAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGE
FGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLSGVEGEGLHK
LGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKL
AEAIFKLTYQNKVVRVQRPTPRGTVMDIISRRDQRGSGQVVTYGLNTFTN
MEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGDD
CVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFH
ELIMKDGRVLVVPCRNQDELIGRARISQGAGWSLRETACLGKSYAQMWSL
MYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWN
RVWIQENPWMEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQ
TAINQVRSLIGNEEYTDYMPSMKRF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7xd9 Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases.
Resolution2.58 Å
Binding residue
(original residue number in PDB)		R404 S405 S661 G662 D664 C709 S710 R729 L754 Y758 M761 T790 S791 R792
Binding residue
(residue number reindexed from 1)		R140 S141 S397 G398 D400 C445 S446 R465 L490 Y494 M497 T526 S527 R528
Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0039694 viral RNA genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7xd9, PDBe:7xd9, PDBj:7xd9
PDBsum7xd9
PubMed36577062
UniProtQ91H74

[Back to BioLiP]