Structure of PDB 7qo4 Chain J Binding Site BS02

Receptor Information
>7qo4 Chain J (length=405) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTAAVTSSNIVLETHESGIKPYFEQKIQETELKIRSKTENVRRLEAQRNA
LNDKVRFIKDELRLLQEPGSYVGEVIKIVSDKKVLVKVQPEGKYIVDVAK
DINVKDLKASQRVCLRSDSYMLHKVLENKADPLVSLMMVEKVPDSTYDMV
GGLTKQIKEIKEVIELPVKHPELFESLGIAQPKGVILYGPPGTGKTLLAR
AVAHHTDCKFIRVSGAELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEI
DSIGSTRVEGSGGGDSEVQRTMLELLNQLDGFETSKNIKIIMATNRLDIL
DPALLRPGRIDRKIEFPPPSVAARAEILRIHSRKMNLTRGINLRKVAEKM
NGCSGADVKGVCTEAGMYALRERRIHVTQEDFELAVGKVMNKNQETAISV
AKLFK
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain7qo4 Chain J Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7qo4 Allosteric control of Ubp6 and the proteasome via a bidirectional switch.
Resolution7.0 Å
Binding residue
(original residue number in PDB)		G192 T193 G194 K195 T196 I330 K359
Binding residue
(residue number reindexed from 1)		G192 T193 G194 K195 T196 I330 K359
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0019904 protein domain specific binding
GO:0031625 ubiquitin protein ligase binding
GO:0036402 proteasome-activating activity
Biological Process
GO:0006289 nucleotide-excision repair
GO:0006338 chromatin remodeling
GO:0010604 positive regulation of macromolecule metabolic process
GO:0032968 positive regulation of transcription elongation by RNA polymerase II
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0070651 nonfunctional rRNA decay
GO:0070682 proteasome regulatory particle assembly
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0034515 proteasome storage granule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7qo4, PDBe:7qo4, PDBj:7qo4
PDBsum7qo4
PubMed
UniProtQ01939|PRS8_YEAST 26S proteasome regulatory subunit 8 homolog (Gene Name=RPT6)

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