Structure of PDB 7q0p Chain J Binding Site BS02

Receptor Information
>7q0p Chain J (length=203) Species: 237561 (Candida albicans SC5314) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GISRDSRHKRSATGAKRAQFRKKRKFELGRQPANTKIGPKRIHSVRTRGG
NQKFRALRVETGNFSWGSEGVSRKTRIAGVVYHPSNNELVRTNTLTKSAV
VQIDATPFRQWYENHYGATLGKKKGGAHAAHAAEVADAKRSRKVERKLAA
RSGAAAIESAVDSQFGSGRLYAVISSRPGQSGRCDGYILEGEELAFYLRR
LTA
Ligand information
>7q0p Chain A (length=1692) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguauacuuggauaaccgugguaau
ucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggauguauu
uauuagauaaaaauuugaugauucauaauaacuuuucgaaucgcauggcc
uugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugg
uaggauaguggccuaccaugguuucaacggguaacggggaauaaggguuc
gauuccggagagggagccugagaaacggcuaccacauccaaggaaggcag
caggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaau
aacgauacagguuguaauuggaaugaguacaauguaaauaccuuaacgag
gaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuc
caaaagcguauauuaaaguuguugcaguuaaaaagcucguaguugaaccu
ugggcuuggcuggccgguccuggacccagccgagccuuuccuucuggcca
ggacuuuuacuuugaaaaaauuagaguguucaaagcaggccuuugcucga
auauauuagcauggaauaauagaauaggacguuaugguucuauuuuguug
guuucuaggaccaucguaaugauuaauagggacggucggggguaucagua
uucaguugucagaggugaaauucuuggauuuacugaagacuaacuacugc
gaaagcauuuaccaaggacguuuucauuaaucaagaacgaaaguuagggg
aucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgac
uagggaucgguuguuguucuuuuauugacgcaaucggcaccuuacgagaa
aucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuua
aaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuu
gacucaacacggggaaacucaccagguccagacacaauaaggauugacag
auugagagcucuuucuugauuuugugggugguggugcauggccguucuua
guugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaa
ccuacuaaauagugcugcuagcauuugcugguauagucacuucuuagagg
gacuaucgauuucaagucgauggaaguuugaggcaauaacaggucuguga
ugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcg
aguauaagccuuggccgagaggucugggaaaucuugugaaacuccgucgu
gcuggggauagagcauuguaauuguugcucuucaacgaggaauuccuagu
aagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacaca
ccgcccgucgcuacuaccgauugaauggcuuagugaggccuccggauugg
uuuagggaaccgagaagcuggucaaacuuggucauuuagaggaaguaaaa
gucguaacaagguuuccguaggugaaccugcggaaggaucau
...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<....<<..........>>...>>.>>......<<..
......<<<..<<..<<....<<<.........<<.....<..<<<....
.>>>..>......>>........<<<<<..<<....>>..>>>>><...<
<<<<<....................>>>>>>.....>...<<<<..<<<.
....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<
<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>
....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>
>>>>>.........<<<....<<<<...>>>>..>>>..>....>.>...
..<<<<...<..>...>>>>......<<..<...........>..>>...
......<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>
>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<...
.<<<<<<<<<<<<............>>>>>>>>>>>>....<<<<<..>>
>>>...<<<<<.<<.......<<...<.......>..<<<....>>>...
.>>......>>.>>..>>>.........<<<..<<<<<<<<<........
.....>>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..
<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<
....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<.
..<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<
.<<<..<<<<<<<<..<<........>>.>>>>>>>>..>>>...<<..)
)>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>.
.)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<
<........>>..........<<<<<.<....<<<<<........<<.<<
<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....
<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.
<<..<<<<..<<<<.<<<<<<<....>>>>>>>....>>>>..>>>>.>>
....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>.....>
>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......
<<......<<<.<<<<....>>>>.>>>....>>.......>>>>>>>..
....<....<<<<<<..........>>>>>>....>.....>>>>>>...
.<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>..
..<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<
<.......>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...
>.>>...>.....<<<<<<<<<<..>>>>>>>>>>.......
Receptor-Ligand Complex Structure
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PDB7q0p E-site drug specificity of the human pathogen Candida albicans ribosome.
Resolution2.77 Å
Binding residue
(original residue number in PDB)
G2 R5 R8 H9 K10 R11 A13 T14 A16 A19 F21 R22 K23 K24 R25 K26 F27 L29 G30 R31 Q32 P33 A34 K41 R42 I43 H44 R47 T48 R49 G50 N52 K54 R56 R59 N64 S66 S73 R74 K75 S86 K98 S99 S142 R143 K144 V145 R147 K148 R152 S176 R178 Q181 S182 R184 D186
Binding residue
(residue number reindexed from 1)
G1 R4 R7 H8 K9 R10 A12 T13 A15 A18 F20 R21 K22 K23 R24 K25 F26 L28 G29 R30 Q31 P32 A33 K40 R41 I42 H43 R46 T47 R48 G49 N51 K53 R55 R58 N63 S65 S72 R73 K74 S85 K97 S98 S141 R142 K143 V144 R146 K147 R151 S175 R177 Q180 S181 R183 D185
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0009986 cell surface
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7q0p, PDBe:7q0p, PDBj:7q0p
PDBsum7q0p
PubMed35613268
UniProtQ59T44|RS8A_CANAL Small ribosomal subunit protein eS8 (Gene Name=RPS8A)

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