Structure of PDB 7k3u Chain J Binding Site BS02

Receptor Information
>7k3u Chain J (length=362) Species: 1358 (Lactococcus lactis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSKIERISAFLNDKEVDMTFITNPTTLNYLTGLAIDPHERIAGLMIFRDS
TPMLFTPALEVEKAKEHTSGLDIFGYEDSQNPWEVVKNHVKSDVKSIAVE
FSDIPLAKTEGLKAQFGDINFVNLTPLIERMRLIKSADEIEKMKVAGDFA
DKCFEIGFATAAERNGVTESDIVAKIEYEMKRMGVPQMSFDTLVLSGARA
ANPHGAPENVEIQENKLLLFDLGVMSGGYASDATRTIAIGQPNDFDAEIH
KIVKEAQQAAMDFIKPGVTAHEVDAVARDLITKAGYGEYFNHSLGHGIGM
DVHEYPSIVAGNDLVIQEGMCFSNEPGIYIPGKVGVRIEDCLYVTENGCE
SFTHTDHDLLIF
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain7k3u Chain J Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7k3u Crystallographic structure of recombinant Lactococcus lactis prolidase to support proposed structure-function relationships.
Resolution2.7 Å
Binding residue
(original residue number in PDB)
D232 H296 S323 E325 E339
Binding residue
(residue number reindexed from 1)
D232 H296 S323 E325 E339
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H204 T234 E325
Catalytic site (residue number reindexed from 1) H204 T234 E325
Enzyme Commision number 3.4.13.9: Xaa-Pro dipeptidase.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0016805 dipeptidase activity
GO:0046872 metal ion binding
GO:0102009 proline dipeptidase activity

View graph for
Molecular Function
External links
PDB RCSB:7k3u, PDBe:7k3u, PDBj:7k3u
PDBsum7k3u
PubMed28179139
UniProtA8WBX8

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