Structure of PDB 6hc3 Chain J Binding Site BS02
Receptor Information
>6hc3 Chain J (length=191) Species:
9606
(Homo sapiens) [
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SVLASCPKKPVSSYLRFSKEQLPIFKAQNPDAKTTELIRRIAQRWRELPD
SKKKIYQDAYRAEWQVYKEEISRFKEQLTPSQIMSLEKEIMDKHLKRKAM
TKKKELTLLGKPKRPRSAYNVYVAERFQEAKGDSPQEKLKTVKENWKNLS
DSEKELYIQHAKEDETRYHNEMKSWEEQMIEVGRKDLLRRT
Ligand information
>6hc3 Chain L (length=22) [
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tttggtggaaattttttgttag
Receptor-Ligand Complex Structure
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PDB
6hc3
DNA specificities modulate the binding of human transcription factor A to mitochondrial DNA control region.
Resolution
3.1 Å
Binding residue
(original residue number in PDB)
S55 Y57 L58 T78 I81 R82 A85 W88 R89 Q100 Y103 W107 K139 M143 K146 K147 K156 R157 N163 V166 F170 P178
Binding residue
(residue number reindexed from 1)
S12 Y14 L15 T35 I38 R39 A42 W45 R46 Q57 Y60 W64 K96 M100 K103 K104 K113 R114 N120 V123 F127 P135
Binding affinity
PDBbind-CN
: Kd=13.6nM
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:6hc3
,
PDBe:6hc3
,
PDBj:6hc3
PDBsum
6hc3
PubMed
31114891
UniProt
Q00059
|TFAM_HUMAN Transcription factor A, mitochondrial (Gene Name=TFAM)
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