Structure of PDB 5t2a Chain J Binding Site BS02

Receptor Information
>5t2a Chain J (length=211) Species: 5661 (Leishmania donovani) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ARRPSRCYRFCKNKPYPKSRFCRGVPDPKIRNFDIGRRRATVDEFPVCIH
VVSRELEQIASEALEAARIQANKYMVKRANKDVFHMRTRAHPFHVLRINK
MLSCAGADRLQTGMRGAFGKPNGVCARVRIGQILLSMRTKEAYVPQAFEA
LRRAKMKFPGRQIIVMSKYWGFTNILRTEYEALRDAGKLEQRGTHCKLIA
PKGKITMRNVM
Ligand information
>5t2a Chain B (length=1064) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cccaacugcagaccguacucaucaccgcaucagguccccaagcauagaau
gcucugguacauagagaaagguacacucagggaagucggcaaaauagaug
cguaaguucgcaagaagcauuggcucugagggcaauugccaacucagaac
ugcuuacggcggggaauccaacuguauaauuaaaacauagguuugugaug
cauccaagugguguauaucgcaaacugauuucugcccagugcucugaaug
ucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaacuau
gacucucuuaagguagccaaaugccucgucuuccaauuagagacgcgcau
gaauggauuaaugagauucccucugucccgaguuacuaucuagcgaaacg
acagucaagggaacggacuugaagggcuaagcggggaaagaagacccugu
ugaguuugacuccagucuggcucugugcggcgacguugcuucacuuaucg
aaugaagagaccaaugggcgugcuguaaacugaaccaacggguccggagu
cuuguuucgagacaucugccagauggggaguuuggcuggggcggcauauc
uguuacacgacaacgcagguguccuaaggcgagcucagugggaacagaaa
ucucacguagaacacaagcguaaaagcuugcuugauuaacgauuuccagu
acgaaucgagacugcgaaagcaaggccagcgauccuuugcgaagaauagg
aaauaugaacaaaucauaccagaggugucagaauaauuaccacagggaua
acuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuu
cgaugucggcucuuccuaaccuagcgccgcagaagacgcuaaggguugga
uuguucacccacugacagggaacgugagcuggguuuagaccgucgugaga
cagguugguuuuacccuacuuagcuggaaauugcgagaaaagauuauccg
cgcaaagcggaggcaguccgucugggucugccguucgguggcaugugcuu
ggcgcugccaucuc
........................<<......>>......<<<<.....>
>>>........<<<<....<<<<.<<<<.<<.........<.....<<<<
<...............>>>>><<.<<<<<<<<<<..>>>>..>>>>>>.>
>..........<<<<<<<<<..<<<.........>>>..<<<<<<<....
<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<
<....<<<<......>>>>....>>..>>>>..>>>>><<<<<<......
.>>>>>>........<...........<<<<<.......>>>>>.....>
.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>........
....<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.
<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<..>>>>>.>>>...<<<
<<.....<<<<...........................<<<..>>>..>>
>>...>>>>>.......>>>>>>>..>>>>>...<<<.....>>>..<<<
<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......
>>>>>>.....<<......>>....>>>>>>>...<<...<<<<<.....
..>>>>>..>>.<<<....>>>.>>........<<<<<<...........
...<<<<.......>>>>.>>>>>>.........>>>>..>>>>>>....
...<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>..
.....<<<<<.<<<<<<..<<<<<<<.<......>.>>>>..>>>.<<<.
........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>
>.>>>>....>>..>>>.>>>>>>>......................<<<
<.....>>>>.<<<<<<<<....>>>.>>>>>....<<<<<<<..<....
...>.>>>>>>>..
Receptor-Ligand Complex Structure
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PDB5t2a Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		R3 R4 S6 R7 R10 F22 E63 A64 A67 Q71 K74 R110 G114 M115 R116 F119 R154 M157 K158
Binding residue
(residue number reindexed from 1)		R2 R3 S5 R6 R9 F21 E62 A63 A66 Q70 K73 R109 G113 M114 R115 F118 R153 M156 K157
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5t2a, PDBe:5t2a, PDBj:5t2a
PDBsum5t2a
PubMed27752045
UniProtA0A3S5H5C4

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