Structure of PDB 4uuv Chain J Binding Site BS02

Receptor Information

>4uuv Chain J (length=94) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAM
NYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPDALFSMAFPD

Ligand information

>4uuv Chain L (length=10) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

acttccggtc

Receptor-Ligand Complex Structure

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PDB	4uuv Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation.
Resolution	2.8 Å
Binding residue (original residue number in PDB)	Q342 L343 W381 K385 R387 D393 K394 R397 S398 Y402 P433
Binding residue (residue number reindexed from 1)	Q2 L3 W41 K45 R47 D53 K54 R57 S58 Y62 P93

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003700	DNA-binding transcription factor activity
GO:0043565	sequence-specific DNA binding

	Biological Process
GO:0006355	regulation of DNA-templated transcription
GO:0006357	regulation of transcription by RNA polymerase II

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Molecular Function

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Biological Process

External links

PDB	RCSB:4uuv, PDBe:4uuv, PDBj:4uuv
PDBsum	4uuv
PubMed	25866208
UniProt	P43268\|ETV4_HUMAN ETS translocation variant 4 (Gene Name=ETV4)

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