Structure of PDB 8x15 Chain I Binding Site BS02

Receptor Information
>8x15 Chain I (length=792) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KSHAEIAEQAKHEAEIETRIAELRKEGFWSLKRLPKVPEPPRPKGHWDYL
CEEMQWLSADFAQERRWKRGVARKVVRMVIRHHEEQRQKEERARREEQAK
LRRIASTMAKDVRQFWSNVEKVVQFKQQSRLEEKRKKALDLHLDFIVGQT
EKYSDLLSQSLNTQVKTPIPLLLRGQLREYQHIGLDWLVTMYEKKLNGIL
ADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCP
SFKILTYYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWR
YLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHF
LEHVIRCRLSKRQRCLYDDFMAQTTTKETLATGHFMSVINILMQLRKVCN
HPNLFDPRPVTSPFITPGICFSTASLVLRATDVHPLQRIDMGRFDLIGLE
GRVSRYEADTFLPRHRLSRRVLLEVATAPDPPPRPKPVKMPFYLDSLEEK
RKRQRSERLERIFQLSEAHGALAPVYGTEVLDFCTLPQPVASPIGPRSPG
PSHPTFWTYTEAAHRAVLFPQQRLDQLSEIIERFIFVMPPVEAPPPSLHA
CHPPPWLAPRQAAFQEQLASELWPRARPLHRIVCNMRTQFPDLRLIQYDC
GKLQTLAVLLRQLKAEGHRVLIFTQMTRMLDVLEQFLTYHGHLYLRLDGS
TRVEQRQALMERFNADKRIFCFILSTRSGGVGVNLTGADTVVFYDSDWNP
TMDAQAQDRCHDVHIYRLISERTVEENILKKANQKRMLGDMA
Ligand information
>8x15 Chain Y (length=137) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cccggtgccgaggccgctcaattggtcgtagacagctctagcaccgctta
aacgcacgtacgcgctgtcccccgcgttttaaccgccaaggggattactc
cctagtctccaggcacgtgtcacatatatacatcctg
Receptor-Ligand Complex Structure
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PDB8x15 Structure of nucleosome-bound SRCAP-C in the apo state
Resolution3.2 Å
Binding residue
(original residue number in PDB)		R156 R736 R737
Binding residue
(residue number reindexed from 1)		R66 R295 R296
Enzymatic activity
Enzyme Commision number 3.6.4.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0004386 helicase activity
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0042393 histone binding
GO:0140658 ATP-dependent chromatin remodeler activity
Biological Process
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0000786 nucleosome
GO:0000812 Swr1 complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005794 Golgi apparatus
GO:0016604 nuclear body
GO:0032991 protein-containing complex
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8x15, PDBe:8x15, PDBj:8x15
PDBsum8x15
PubMed38331872
UniProtQ6ZRS2|SRCAP_HUMAN Helicase SRCAP (Gene Name=SRCAP)

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