Structure of PDB 8ui0 Chain I Binding Site BS02

Receptor Information
>8ui0 Chain I (length=114) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITHE
VDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLY
YVCTAPHCGHRWTE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8ui0 Chain I Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8ui0 Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		C86 C114 C119
Binding residue
(residue number reindexed from 1)		C75 C103 C108
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0001193 maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex
GO:0005730 nucleolus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ui0, PDBe:8ui0, PDBj:8ui0
PDBsum8ui0
PubMed38401543
UniProtP60899|RPB9_PIG DNA-directed RNA polymerase II subunit RPB9 (Gene Name=POLR2I)

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