Structure of PDB 8qu5 Chain I Binding Site BS02

Receptor Information
>8qu5 Chain I (length=158) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKAVTRHRRVMHFQRQKLMAVTEYIPPKPAIHPSCLPGLIRLLRREIAAV
FQDNRMIAVCQNVALSAEDKLLMRHQLRKHKILMKVFPNQVLKPFLEDSK
YQNLLPLFVGHNMLLVSEEPKVKEMVRILRTVPFLPLLGGCIDDTILSRQ
GFINYSKL
Ligand information
>8qu5 Chain A (length=1049) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccacuccaccuuacuaccaaaccuuagccaa
accauuuacauaaaguauaggcgauagaaauugggcgcaauagauauagu
accgcaagggaaagaugaaaaauaccaagcauaauauagcaaggacuaac
cccuauaccuucugaugaauuaacuagaaauaacuuugcaaggagagcca
aagcuaagacccccgaaaccagacgagcgccuggugauagcugguugucc
aagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaaucccc
uuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuagg
aaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaa
aagcagccaccaauuaagaaagcguucaagcucaacaccucccaaacaua
uaacugaacuccucacacccaauuggaccaaucuaucacccuauagaaga
acuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccug
cgucagaucacugacaauuaacagcccaauaucuacaaucaaccaacaag
ucauuauuacccucacugucaacccaacaggcaugcucauaaggaaaggu
uaaaaaaaguaaaaggaaacaucaccucuagcaucaccaguauuagaggc
cagcugucucuuacuuuuaaccagugaaauugaccugcccgugaggcggg
cauaacacagcaagacgagacccuauggagcuuuaauuuauuaaugcaaa
caccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaacc
uccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauuga
uccaauaacuugaccaacggaacaaguuacccuaggguaucuacuuuauu
ccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgcc
uucuaaaugauaucaucucaacuuaauacccacacccaagaacaggguu
<<<.......<<<<..................................<.
.....>...........<<.....>>.......>>.>>............
.<<....>>..................>>>...........<<<......
.>>>...<.<....>.>.<<<<<<.........<<<.<<..<<....>>.
..>>.>>>...<<.<...<<<<.<....>.>>>>......>.>>..<<<<
<<....<<<<....>>>>.<<.<<<<<<<<<<.....<<......>>...
..>>>>>>>>>>..>>..<<<<<<<<<<......>>>>>>>>>>...<<<
......>>>....<<<.<<<...<..............<....<<<....
.....>>>....>.......<<<......>>>..................
....>...>>>>>>........>>>>>>...<<<<<......>>>>>...
......>>>>>><......<<..<<<....>>><<<<..<<<<.......
.<<<<<....>>>>>......<<<...<<<<...................
....>>>>.......>>>.....<<....>>.>>>>.....>>>>..<<<
<...<<<<<<<<.<<.........<<<<<<.............>>>>>>.
.......>>.>>>>>>>>>>>>.>>.....>.....<<<<<.....>>>>
>.......<<..<<<.....<<<<<.<<<<<<..<<<<<.<<<<<<<<..
....>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>
>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.......
..<<<....>>>............>>>>..>>>>>>>..>>>.>>..<<<
.<<<.................>>>.>>><<<<<...<<<....>>>.>>>
>>.<<<.<............>.>>>........<<<<.......>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8qu5 GTPBP8 plays a role in mitoribosome formation in human mitochondria.
Resolution2.42 Å
Binding residue
(original residue number in PDB)		K31 V33 T34 R35 H41 Q43 K46 A106 V125 F126 P127 N128 G149 H150
Binding residue
(residue number reindexed from 1)		K2 V4 T5 R6 H12 Q14 K17 A67 V86 F87 P88 N89 G110 H111
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8qu5, PDBe:8qu5, PDBj:8qu5
PDBsum8qu5
PubMed38969660
UniProtQ7Z7H8|RM10_HUMAN Large ribosomal subunit protein uL10m (Gene Name=MRPL10)

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