Structure of PDB 7oi9 Chain I Binding Site BS02

Receptor Information

>7oi9 Chain I (length=158) Species: 9606 (Homo sapiens)

SKAVTRHRRVMHFQRQKLMAVTEYIPPKPAIHPSCLPGLIRLLRREIAAV
FQDNRMIAVCQNVALSAEDKLLMRHQLRKHKILMKVFPNQVLKPFLEDSK
YQNLLPLFVGHNMLLVSEEPKVKEMVRILRTVPFLPLLGGCIDDTILSRQ
GFINYSKL

Ligand information

>7oi9 Chain A (length=1092)

gcuaaaccuagccccaaacccacuccaccuuacuaccaaaccuuagccaa
accauuuacauaaaguauaggcgauagaaauugggcgcaauagauauagu
accgcaagggaaagaugaaaaauaccaagcauaauauagcaaggacuaac
cccuauaccuucugaugaauuaacuagaaauaacuuugcaaggagagcca
aagcuaagacccccgaaaccagacgagcuaccuaagaacagauuuauagg
uagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauag
aaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaa
uuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaac
cuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagc
caccaauuaagaaagcguucaagcucaacaccucccaaacauauaacuga
acuccucacacccaauuggaccaaucuaucacccuauagaagaacuaaug
uuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucaga
ucacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuau
uacccucacugucaacccaacaggcaugcucauaaggaaagguuaaaaaa
aguaaaaggaaacaucaccucuagcaucaccaguauuagaggccagcugu
cucuuacuuuuaaccagugaaauugaccugcccgugaggcgggcauaaca
cagcaagacgagacccuauggagcuuuaauuuauuaaugcaaacaccugc
auuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagc
aguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaaua
acuugaccaacggaacaaguuacccuaggguaucuacuuuauuccucccu
guacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucuaaa
ugauaucaucucaacuuaauacccacacccaagaacaggguu

<<<.......<<<<..................................<.
.....>.....<.....<<.....>>....>..>>.>>............
.<<....>>..................>>>...........<<<......
.>>>...<.<....>.>.<<<<<<.........<<<.<<..<<....>>.
..>>.>>>...<<.<...<<<<.<.....<<<<<.<<<....>>>.>>>>
>...<<.......>>......>.>>>>......>.>>..<<<<<<....<
<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>
>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>
>>....<<<.<<<...<..............<....<<<.........>>
>....>.......<<<......>>>......................>..
.>>>>>>........>>>>>>...<<<<<......>>>>>.........>
>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<.
...>>>>>......<<<...<<<<.......................>>>
>.......>>>.....<<....>>.>>>>.....>>>>..<<<<...<<<
<<<<<.<<.........<<<<<<.............>>>>>>........
>>.>>>>>>>>>>>>.>>.....>.....<<<<<.....>>>>>......
.<<..<<<.....<<<<<.<<<<<<..<<<<<.<<<<<<<<......>>>
>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..
<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<..
..>>>............>>>>..>>>>>>>..>>>.>>..<<<.<<<...
..............>>>.>>><<<<<...<<<....>>>.>>>>>.<<<.
<............>.>>>........<<<<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7oi9 A distinct assembly pathway of the human 39S late pre-mitoribosome.
• Resolution: 3.3 Å
• Binding residue (original residue number in PDB): K31 V33 T34 R35 R38 H41 K46 A106 V125 P127 N128 Q129 G149 H150
• Binding residue (residue number reindexed from 1): K2 V4 T5 R6 R9 H12 K17 A67 V86 P88 N89 Q90 G110 H111

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005654 nucleoplasm
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7oi9, PDBe:7oi9, PDBj:7oi9
• PDBsum: 7oi9
• PubMed: 34315873
• UniProt: Q7Z7H8|RM10_HUMAN Large ribosomal subunit protein uL10m (Gene Name=MRPL10)