Structure of PDB 7mft Chain I Binding Site BS02

Receptor Information
>7mft Chain I (length=490) Species: 535026 (Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPTGFMEIKREKPAERDPLTRLKDWKEYSAPFSEEASKRQGARCMDCGTP
FCQIGADINGFTSGCPIYNLIPEWNGLVYRGRWKEALERLLKTNNFPEFT
GRVCPAPCEGSCTLAISDPAVSIKNIERTIIDKGFENGWIQPRIPKKRTG
KKVAIVGSGPAGLASADQLNQAGHSVTVFERADRAGGLLTYGIPNMKLEK
GIVERRIKLLTQEGIDFVTNTEIGVDITADELKEQFDAVILCTGAQKQRD
LLIEGRDSKGVHYAMDYLTLATKSYLDSNFKDKQFIDAKGKDVIVIGGGD
TGADCVATALRQKAKSVHQFGKHPKLPPARTNDNMWPEQPHVFTLEYAYE
EAEAKFGRDPREYSIQTTKMVADKNGKLKELHTIQMEKVKNEHGKYEFRE
LPGTEKVWPAQLVFIAIGFEGTEQPLLKQFGVNSVNNKISAAYGDYQTNI
DGVFAAGDARRGQSLIVWAINEGREVAREVDRYLMGSSVL
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain7mft Chain I Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7mft A counter-enzyme complex regulates glutamate metabolism in Bacillus subtilis.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		C46 C49 P52 C54 C114 T115 L116 V123
Binding residue
(residue number reindexed from 1)		C44 C47 P50 C52 C112 T113 L114 V121
Annotation score1
Enzymatic activity
Enzyme Commision number 1.4.1.13: glutamate synthase (NADPH).
Gene Ontology
Molecular Function
GO:0004355 glutamate synthase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
GO:0051536 iron-sulfur cluster binding
Biological Process
GO:0006537 glutamate biosynthetic process
GO:0097054 L-glutamate biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7mft, PDBe:7mft, PDBj:7mft
PDBsum7mft
PubMed34931064
UniProtO34399|GLTB_BACSU Glutamate synthase [NADPH] small chain (Gene Name=gltB)

[Back to BioLiP]