Structure of PDB 7b0n Chain I Binding Site BS02

Receptor Information
>7b0n Chain I (length=191) Species: 4952 (Yarrowia lipolytica) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
INIYAGGSAAAAPPAGFRIHRPATWEESEEGALSKATKYFLLAEMFRGLY
VVLEQFFRAPYTIYYPFEKGPVSPRFRGEHALRRYPSGEERCIACKLCEA
ICPALAITIDAEERIDGSRRTTKYDIDMTKCIYCGYCQESCPVDAIVETP
NVEYATETREELLYNKEKLLANGDKWELELQYALDADAPYR
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain7b0n Chain I Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7b0n A conserved arginine residue is critical for stabilizing the N2 FeS cluster in mitochondrial complex I.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		H315 C337 C366 I367 Y368 C369 G370 C372 E383
Binding residue
(residue number reindexed from 1)		H80 C102 C131 I132 Y133 C134 G135 C137 E148
Annotation score4
Enzymatic activity
Enzyme Commision number 1.6.99.3: Deleted entry.
Gene Ontology
Molecular Function
GO:0016651 oxidoreductase activity, acting on NAD(P)H
GO:0051539 4 iron, 4 sulfur cluster binding
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
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Cellular Component
External links
PDB RCSB:7b0n, PDBe:7b0n, PDBj:7b0n
PDBsum7b0n
PubMed33640456
UniProtQ9UUT8

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