Structure of PDB 7arc Chain I Binding Site BS02

Receptor Information

>7arc Chain I (length=199) Species: 37502 (Polytomella sp. Pringsheim 198.80)

GTERRPGQSGAWKQVDKQRYSSEWEQDPTFKQVPKNVSEVLDDSVSVLFL
TDIVRGMMYSASGFFDDKVTILYPFEKGAVSPRFRGEHALRRYPTGEERC
ISCKLCEAICPAQAITIEAEEREDGSRKTTRYDIDMTKCIYCGFCQEACP
VDAIVEGPNFEFSTETREELLYDKQKLLENGDKWEQEIAANLRTESLYR

Ligand information

• Ligand ID: SF4
• InChI: InChI=1S/4Fe.4S
• InChIKey: LJBDFODJNLIPKO-UHFFFAOYSA-N
• SMILES:
  OpenEye OEToolkits 2.0.7: [S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
  CACTVS 3.385: S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
• Formula: Fe4 S4
• Name: IRON/SULFUR CLUSTER
• PDB chain: 7arc Chain I Residue 500

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7arc A ferredoxin bridge connects the two arms of plant mitochondrial complex I.
• Resolution: 2.88 Å
• Binding residue (original residue number in PDB): H118 C140 P141 I145 C169 I170 Y171 C172 G173 F174 C175 E186
• Binding residue (residue number reindexed from 1): H88 C110 P111 I115 C139 I140 Y141 C142 G143 F144 C145 E156
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0003954 NADH dehydrogenase activity
• GO:0016651 oxidoreductase activity, acting on NAD(P)H
• GO:0051539 4 iron, 4 sulfur cluster binding

Biological Process

• GO:0006120 mitochondrial electron transport, NADH to ubiquinone
• GO:0032981 mitochondrial respiratory chain complex I assembly

Cellular Component

• GO:0005739 mitochondrion
• GO:0016020 membrane

External links

• PDB: RCSB:7arc, PDBe:7arc, PDBj:7arc
• PDBsum: 7arc
• PubMed: 33768254
• UniProt: A0A7S0UQ60