Structure of PDB 7a5j Chain I Binding Site BS02

Receptor Information
>7a5j Chain I (length=158) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKAVTRHRRVMHFQRQKLMAVTEYIPPKPAIHPSCLPGLIRLLRREIAAV
FQDNRMIAVCQNVALSAEDKLLMRHQLRKHKILMKVFPNQVLKPFLEDSK
YQNLLPLFVGHNMLLVSEEPKVKEMVRILRTVPFLPLLGGCIDDTILSRQ
GFINYSKL
Ligand information
>7a5j Chain A (length=1492) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccccaccuuacuaccaaaccuuagccaaacc
auuuacauaaaguauaggcgauagaaauugggcgcaauagauauaguacc
gcaagggaaagaugaaaaaaccaagcauaauauagcaaggacuaaccccu
auaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagcca
aagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaagagca
cacccgucuauguagcaaaauagugggaagauuuauagguagaggcgaca
aaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguuc
aacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguua
guccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagag
aguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaag
aaagcguucaagcucaacacaaaaaucccaaacauauaacugaacuccuc
acacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguau
aaguaacaugaaaacauucuccuccgcauaagccugcgucagcaacugac
aauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccuca
cugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaa
aggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucua
gcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacgg
ccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaau
agggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuua
accagugaaauugaccugcccgugaagaggcgggcauaacacagcaagac
gagaagacccuauggagcuuuaauuuauuaaugcaaacaguaccuaacaa
acccacagguccuaaacuaccaaaccugcauuaaaaauuucgguuggggc
gaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucacc
agucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguu
acccuagggauaacagcgcaauccuauucuagaguccauaucaacaauag
gguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcua
uuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucag
accggaguaauccaggucgguuucuaucuacuuuauuccucccuguacga
aaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaau
gauaucaucucaacuuagauacccacacccaagaacaggguu
<<<.......<<<<...............................<....
..>...........<<.....>>.......>>.>>.............<<
....>>.................>>>...........<<<.......>>>
...<.<........>.>.<<<<<<.........<<<.<<..<<....>>.
..>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<...>>>.
..<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.....
..>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>>
<<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.
<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<
<<...<..............<....<<<.........>>>....>.....
..<<<......>>>..........................>...>>>>>>
........>>>>>>...<<<<<......>>>>>.........>>>>>>..
.....<<..<<<....>>><<<<..<<<<........<<<<<...>>>>>
......<<<...<<<<.......................>>>>.......
>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.
<<.........<......<<<<<<..<<<.........>>>...<<<<<<
.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>
>...<<........>>...........<...........<<<<<<.....
>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>
>>>.>>...........<<<<<........>>>>>.......<<..<<<.
<<......<<<<.<<<<<<..<<<<<.<<<<<<<<...............
<<<....>>>................>>>>>>>>>>>>>..<<<<.....
>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....
>>>>..>>>....>>...........<....>..............>>>>
..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>
>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>
>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<
<<<<<<....>>>.>>>>....>>..>>>.>>..<<<.<<<.........
........>>>.>>><<<<<...<<<....>>>.>>>>>......<<<..
..............>>>.........<<<<.......>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7a5j Elongational stalling activates mitoribosome-associated quality control.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		K31 V33 R35 R38 H41 Q43 A106 R113 V125 P127 N128 G149 H150
Binding residue
(residue number reindexed from 1)		K2 V4 R6 R9 H12 Q14 A67 R74 V86 P88 N89 G110 H111
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7a5j, PDBe:7a5j, PDBj:7a5j
PDBsum7a5j
PubMed33243891
UniProtQ7Z7H8|RM10_HUMAN Large ribosomal subunit protein uL10m (Gene Name=MRPL10)

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