Structure of PDB 6rfl Chain I Binding Site BS02

Receptor Information
>6rfl Chain I (length=773) Species: 502057 (Vaccinia virus GLV-1h68) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DSKETILIEIIPKIKAYLLDANISPKSYDDFISRNKNIFVINLYNVSTIT
EEDIRLLYTTIEQNIDADDQTLVAIFSYIGYKFEQAVKEEISTSLSFNDK
NTTDEMTYNLYDLFFNTLDMYLRQKKISILVNDDVVIVSYKPEIKKIPFN
MKNLLPYLEKNLDQLRFSKKYLDFAYLCRHIGIPISKKKYNVRYVFLYKI
DGLSIPIIIKDFLDVKYVYLENTGKIYKNSFSEDHNNSLSDWGKVIIPLL
KDRHLYSYIFLSSYHLHSYYTDLIARDEPVFVKRKKLDIIEIDEPEAWKR
DVRVEFAPCEHQIRLKEAMKVDANYFTKINNFANEFIYYEDGVAYCRVCG
INIPIFNLDAADVIKNTVIVSTFNKTIFLSEPYSYFVHSQRFIFNIIMSF
DNIMKSQTWVMKYNINRLILNFLIDINSRRQEYEKKFSSEIKRGLFFLRL
SANLFETELFYVSKMLNLNYIVALVIILNSSADFIVSYMTSKNKTVEEST
LKYAISVVIYDFLVKTRICEKGSLDTIVLFTDVYTSIMPEELDLHFQRIT
LELRKLVSIQRSALEPNYDVESRGEELPLSALKFFDTSTIIVKTMAPVHT
CVEQKIVAPTPSVEPTDASLKNFKELTCDEDIKILIRVHDTNATKLVIFP
SHLKIEIERKKLIIPLKSLYITNTLKYYYSNSYLYVFRFGDPMPFEEELI
DHEHVQYKINCYNILRYHLLPDSDVFVYFSNSLNREALEYAFYIFLSKYV
NVKQWIDENITRIKELYMINFNN
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6rfl Chain I Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6rfl Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes.
Resolution2.76 Å
Binding residue
(original residue number in PDB)		C326 H328 C363
Binding residue
(residue number reindexed from 1)		C309 H311 C346
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0016779 nucleotidyltransferase activity
Biological Process
GO:0006353 DNA-templated transcription termination
GO:0006355 regulation of DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6rfl, PDBe:6rfl, PDBj:6rfl
PDBsum6rfl
PubMed31835032
UniProtQ1PIU7

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