Structure of PDB 5flv Chain I Binding Site BS02

Receptor Information
>5flv Chain I (length=226) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRR
YKSKRQRVFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVVTGLNPKTK
YILLMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWM
RQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADSTHVFPETAF
IAVTSYQNHKITQLKIENNPFAKGFR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5flv Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis.
Resolution3.005 Å
Binding residue
(original residue number in PDB)		R141 Y161 Q186 R189 Y190 R1081 R1082 K1159 Y1217 T1223 N1230 F1232 F1236
Binding residue
(residue number reindexed from 1)		R2 Y22 Q47 R50 Y51 R83 R84 K160 Y206 T212 N219 F221 F225
Binding affinityPDBbind-CN: Kd~50nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5flv, PDBe:5flv, PDBj:5flv
PDBsum5flv
PubMed26875865
UniProtP42582;
P70326

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