Structure of PDB 3oaa Chain I Binding Site BS02

Receptor Information
>3oaa Chain I (length=488) Species: 536056 (Escherichia coli DH1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EAHNEGTIVSVSDGVIRIHGLADCMQGEMISLPGNRYAIALNLERDSVGA
VVMGPYADLAEGMKVKCTGRILEVPVGRGLLGRVVNTLGAPIDGKGPLDH
DGFSAVEAIAPGVIERQSVDQPVQTGYKAVDSMIPIGRGQRELIIGDRQT
GKTALAIDAIINQRDSGIKCIYVAIGQKASTISNVVRKLEEHGALANTIV
VVATASESAALQYLAPYAGCAMGEYFRDRGEDALIIYDDLSKQAVAYRQI
SLLLRRPPGREAFPGDVFYLHSRLLERAARVNAEYVEAFTKGEVKGKTGS
LTALPIIETQAGDVSAFVPTNVISITDGQIFLETNLFNAGIRPAVNPGIS
VSRVGGAAQTKIMKKLSGGIRTALAQYRELAAFSQFASDLDDATRKQLDH
GQKVTELLKQKQYAPMSVAQQSLVLFAAERGYLADVELSKIGSFEAALLA
YVDRDHAPLMQEINQTGGYNDEIEGKLKGILDSFKATQ
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain3oaa Chain I Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3oaa Structural basis for inhibition of bacterial ATP synthase by subunit epsilon of the rotor stalk
Resolution3.26 Å
Binding residue
(original residue number in PDB)		T176 D261
Binding residue
(residue number reindexed from 1)		T153 D238
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) K175 Q200 K201 R376
Catalytic site (residue number reindexed from 1) K152 Q177 K178 R353
Enzyme Commision number 7.1.2.2: H(+)-transporting two-sector ATPase.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0032559 adenyl ribonucleotide binding
GO:0043531 ADP binding
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process
GO:0006754 ATP biosynthetic process
GO:0015986 proton motive force-driven ATP synthesis
GO:0042777 proton motive force-driven plasma membrane ATP synthesis
GO:0046034 ATP metabolic process
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0045259 proton-transporting ATP synthase complex
GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3oaa, PDBe:3oaa, PDBj:3oaa
PDBsum3oaa
PubMed
UniProtP0ABB0|ATPA_ECOLI ATP synthase subunit alpha (Gene Name=atpA)

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