Structure of PDB 3cjt Chain I Binding Site BS02

Receptor Information
>3cjt Chain I (length=254) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MWVYRLKGTLEALDPILPGLFDGGARGLWEREGEVWAFFPAPVDLPYEGV
WEEVGDEDWLEAWRRDLKPALAPPFVVLAPWHTWEGAEIPLVIEPGMAFG
TGHAETTRLALKALARHLRPGDKVLDLGTGSGVLAIAAEKLGGKALGVDI
DPMVLPQAEANAKRNGVRPRFLEGSLEAALPFGPFDLLVANLYAELHAAL
APRYREALVPGGRALLTGILKDRAPLVREAMAGAGFRPLEEAAEGEWVLL
AYGR
Ligand information
Ligand ID2MM
InChIInChI=1S/C7H15NO2S/c1-8(2)6(7(9)10)4-5-11-3/h6H,4-5H2,1-3H3,(H,9,10)/t6-/m0/s1
InChIKeyFLEXUHXAXRFRAU-LURJTMIESA-N
SMILES
SoftwareSMILES
CACTVS 3.341CSCC[C@H](N(C)C)C(O)=O
CACTVS 3.341CSCC[CH](N(C)C)C(O)=O
OpenEye OEToolkits 1.5.0CN(C)[C@@H](CCSC)C(=O)O
ACDLabs 10.04O=C(O)C(N(C)C)CCSC
OpenEye OEToolkits 1.5.0CN(C)C(CCSC)C(=O)O
FormulaC7 H15 N O2 S
NameN,N-dimethyl-L-methionine
ChEMBLCHEMBL1229963
DrugBank
ZINCZINC000001677421
PDB chain3cjt Chain J Residue 148 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3cjt Multiple-Site Trimethylation of Ribosomal Protein L11 by the PrmA Methyltransferase.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		N191 L192 Y193 G218 L220 W247
Binding residue
(residue number reindexed from 1)		N191 L192 Y193 G218 L220 W247
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.-
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0042054 histone methyltransferase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0006479 protein methylation
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3cjt, PDBe:3cjt, PDBj:3cjt
PDBsum3cjt
PubMed18611379
UniProtQ84BQ9|PRMA_THET8 Ribosomal protein L11 methyltransferase (Gene Name=prmA)

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