Structure of PDB 2wwa Chain I Binding Site BS02

Receptor Information

>2wwa Chain I (length=153) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MARYGATSTNPAKSASARGSYLRVSFKNTRETAQAINGWELTKAQKYLEQ
VLDHQRAIPFRRFNSSIGRTAQGKEFGVTKARWPAKSVKFVQGLLQNAAA
NAEAKGLDATKLYVSHIQVNQAPKQRRRTYRAHGRINKYESSPSHIELVV
TEK

Ligand information

>2wwa Chain F (length=25) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ccacgucaacagcaguuggacgugg

<<<<<<...<<.....>>.>>>>>>

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2wwa Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating Ribosome.
Resolution	8.9 Å
Binding residue (original residue number in PDB)	R23 K86 Q125 R127 T129 Y139
Binding residue (residue number reindexed from 1)	R23 K86 Q125 R127 T129 Y139

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0000448	cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015934	large ribosomal subunit
GO:0022625	cytosolic large ribosomal subunit
GO:0030687	preribosome, large subunit precursor
GO:1990904	ribonucleoprotein complex

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External links

PDB	RCSB:2wwa, PDBe:2wwa, PDBj:2wwa
PDBsum	2wwa
PubMed	19933108
UniProt	P05740\|RL17A_YEAST Large ribosomal subunit protein uL22A (Gene Name=RPL17A)

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