Structure of PDB 1r1l Chain I Binding Site BS02

Receptor Information

>1r1l Chain I (length=416) Species: 9606 (Homo sapiens)

VDICTAKPRDIPMNPMCIYRSPEKKPEATNRRVWELSKANSRFATTFYQH
LADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKT
SDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELV
YGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVL
VNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAE
GTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMM
LVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVS
DAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREV
PLNTIIFMGRVANPCV

Ligand information

>1r1l Chain D (length=3)

LLF

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1r1l Serpins and the design of peptides to block intermolecular beta-linkages
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): F87 T90 V212 L213 V214 L215 Y363 V364 S365 D366
• Binding residue (residue number reindexed from 1): F72 T75 V197 L198 V199 L200 Y348 V349 S350 D351

Gene Ontology

Molecular Function

• GO:0002020 protease binding
• GO:0004867 serine-type endopeptidase inhibitor activity
• GO:0005515 protein binding
• GO:0008201 heparin binding
• GO:0042802 identical protein binding

Biological Process

• GO:0007596 blood coagulation
• GO:0010466 negative regulation of peptidase activity
• GO:0030193 regulation of blood coagulation

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005788 endoplasmic reticulum lumen
• GO:0005886 plasma membrane
• GO:0062023 collagen-containing extracellular matrix
• GO:0070062 extracellular exosome
• GO:0072562 blood microparticle

External links

• PDB: RCSB:1r1l, PDBe:1r1l, PDBj:1r1l
• PDBsum: 1r1l
• UniProt: P01008|ANT3_HUMAN Antithrombin-III (Gene Name=SERPINC1)