Structure of PDB 8jp5 Chain H Binding Site BS02

Receptor Information

>8jp5 Chain H (length=98) Species: 9606 (Homo sapiens)

LDKNTVHDQEHIMEHLEGVINKPEAEMSPQELQLHYFKMHDYDGNNLLDG
LELSTAITHVHQAPLMSEDELINIIDGVLRDDDKNNDGYIDYAEFAKS

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 8jp5 Chain H Residue 702

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8jp5 Structure of full-length ERGIC-53 in complex with MCFD2 for cargo transport.
• Resolution: 2.59 Å
• Binding residue (original residue number in PDB): D81 D83 N85 L87 E92
• Binding residue (residue number reindexed from 1): D41 D43 N45 L47 E52
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding
• GO:0005515 protein binding
• GO:0046872 metal ion binding

Biological Process

• GO:0015031 protein transport
• GO:0016192 vesicle-mediated transport

Cellular Component

• GO:0005783 endoplasmic reticulum
• GO:0005789 endoplasmic reticulum membrane
• GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
• GO:0005794 Golgi apparatus
• GO:0012507 ER to Golgi transport vesicle membrane
• GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane

External links

• PDB: RCSB:8jp5, PDBe:8jp5, PDBj:8jp5
• PDBsum: 8jp5
• PubMed: 38493152
• UniProt: Q8NI22|MCFD2_HUMAN Multiple coagulation factor deficiency protein 2 (Gene Name=MCFD2)