Structure of PDB 8gri Chain H Binding Site BS02

Receptor Information

>8gri Chain H (length=469) Species: 285500 (Streptomyces luteocolor) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

VIVVGNGVLGLSVGVEIARTRPDVRVTLLGKPARQYGATPAAGAMLGAFG
EVTAHALASEHGRKKHALAVQAQRLWPEWIESLEATGTAADGRIKTADDT
VVLLNTVGHSALDDANFAAVLTALKEANAPHEEIAVESVDWIDPDPNSRP
LRALHIEGEGSVDSGILLAALERSFLQAGGRLHPVDATEIRAVVTDDGDF
LPAGHVVVAAGARSQRLVAALAHRIPRIYDGVGVSALVDTWDGSGPATVL
RTSNRAFACGLHLVPRAGGSVYIGATNAVCLEPRGAASIAETVFLFNCAT
HQLHRGLNGSELRKVQVGSRPAPIDGFPLIGGTSVEGLWMLSGTYRDGLH
MSPLLARHVVSLMDGGTGVDGLREFRPERDLISAWSREEILDDVVRHTMA
TGYEFPWRLPLEWPHMMETFLQGPFAELADRLSDTYTPPADLMTAIMFSE
REQQDELIAYYADVHREWH

Ligand information

Ligand ID

GLY

InChI

InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

InChIKey

DHMQDGOQFOQNFH-UHFFFAOYSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 1.5.0	C(C(=O)O)N
CACTVS 3.341	NCC(O)=O
ACDLabs 10.04	O=C(O)CN

Formula

C2 H5 N O2

Name

GLYCINE

PDB chain

8gri Chain H Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8gri N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry.
Resolution	2.365 Å
Binding residue (original residue number in PDB)	H284 R342 R368
Binding residue (residue number reindexed from 1)	H262 R320 R346
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0016491	oxidoreductase activity

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Cellular Component

External links

PDB	RCSB:8gri, PDBe:8gri, PDBj:8gri
PDBsum	8gri
PubMed	37137912
UniProt	A0A125SZC1

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