Structure of PDB 7x74 Chain H Binding Site BS02

Receptor Information
>7x74 Chain H (length=131) Species: 100226 (Streptomyces coelicolor A3(2)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPVKGRATRQRAAVSAALQEVEEFRSAQELHDMLKHKGDAVGLTTVYRTL
QSLADAGEVDVLRTAEGESVYRRCSTGDHHHHLVCRACGKAVEVEGPAVE
KWAEAIAAEHGYVNVAHTVEIFGTCADCAGA
Ligand information
>7x74 Chain P (length=84) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggcgacccggcgccgcctacggtcagtactacgggtagggggtatcgggc
aacgcggcactgaacaccgttgtcatgtgccttg
Receptor-Ligand Complex Structure
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PDB7x74 Structural basis of Streptomyces transcription activation by zinc uptake regulator.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		G10 R11 Q15 R16 V46 G47 T49 T50
Binding residue
(residue number reindexed from 1)		G5 R6 Q10 R11 V41 G42 T44 T45
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0001217 DNA-binding transcription repressor activity
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045892 negative regulation of DNA-templated transcription
GO:1900376 regulation of secondary metabolite biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032993 protein-DNA complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7x74, PDBe:7x74, PDBj:7x74
PDBsum7x74
PubMed35871291
UniProtQ9L2H5

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