Structure of PDB 7rpk Chain H Binding Site BS02

Receptor Information
>7rpk Chain H (length=151) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFK
DEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEE
SLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKA
E
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7rpk Chain H Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7rpk Dispatched uses Na + flux to power release of lipid-modified Hedgehog.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		E90 E91 E127 D130 D132 H134
Binding residue
(residue number reindexed from 1)		E52 E53 E89 D92 D94 H96
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Biological Process
GO:0007267 cell-cell signaling
GO:0007275 multicellular organism development

View graph for
Biological Process
External links
PDB RCSB:7rpk, PDBe:7rpk, PDBj:7rpk
PDBsum7rpk
PubMed34707294
UniProtQ62226|SHH_MOUSE Sonic hedgehog protein (Gene Name=Shh)

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