Structure of PDB 7n0d Chain H Binding Site BS02

Receptor Information
>7n0d Chain H (length=512) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ENVTGLFKDCSKVITGLHPTQAPTHLSVDTKFKTEGLCVDIPGIPKDMTY
RRLISMMGFKMNYQVNGYPNMFITREEAIRHVRAWIGFDVEGCHATREAV
GTNLPLQLGFSTGVNLVAVPTGYVDTPNNTDFSRVSAKPPPGDQFKHLIP
LMYKGLPWNVVRIKIVQMLSDTLKNLSDRVVFVLWAHGFALTSMKYFVKI
GPERTCCLCDRRATCFSTASDTYACWHHSIGFDYVYNPFMIDVQQWGFTG
NLQSNHDLYCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWTIEYPIIGD
ELKINAACRKVQHMVVKAALLADKFPVLHDIGNPKAIKCVPQADVEWKFY
DAQPCSDKAYKIEELFYSYATHSDKFTDGVCLFWNCNVDRYPANSIVCRF
DTRVLSNLNLPGCDGGSLYVNKHAFHTPAFDKSAFVNLKQLPFFYYSDSP
CESYVPLKSATCITRCNLGGAVCRHHANEYRLYLDAYNMMISAGFSLWVY
KQFDTYNLWNTF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7n0d Structural basis of mismatch recognition by a SARS-CoV-2 proofreading enzyme.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		E92 G93 H95 P141 F146 W186 Q245 G251 N252
Binding residue
(residue number reindexed from 1)		E91 G92 H94 P140 F145 W185 Q244 G250 N251
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004532 RNA exonuclease activity
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7n0d, PDBe:7n0d, PDBj:7n0d
PDBsum7n0d
PubMed34315827
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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