Structure of PDB 7k36 Chain H Binding Site BS02

Receptor Information
>7k36 Chain H (length=177) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RNRPGTKAQDFYNWTLAVQQYIQQNIRADCSNIDKILEPPDEGVWKYEHL
RQFCLELNGLAVKLQSECHPDTCIFLCAAHKTPKECPAIDYTRHTLDGAA
CLLNSNKYFPSRVSIKESSVAKLGSVCRRIYRIFSHAYFHHRQIFDEYEN
ETFLCHRFTKFVMKYNLMSKDNLIVPI
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7k36 Chain H Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7k36 Cryo-EM structure of the Hippo signaling integrator human STRIPAK.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		C97 H169 H174
Binding residue
(residue number reindexed from 1)		C73 H136 H141
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0019900 kinase binding
GO:0030674 protein-macromolecule adaptor activity
GO:0046872 metal ion binding
Biological Process
GO:0035331 negative regulation of hippo signaling
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0032580 Golgi cisterna membrane
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0048471 perinuclear region of cytoplasm
GO:0090443 FAR/SIN/STRIPAK complex
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7k36, PDBe:7k36, PDBj:7k36
PDBsum7k36
PubMed33633399
UniProtQ9Y3A3|PHOCN_HUMAN MOB-like protein phocein (Gene Name=MOB4)

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