Structure of PDB 6zgo Chain H Binding Site BS02

Receptor Information
>6zgo Chain H (length=259) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQFGE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6zgo Thrombin in complex with D-Phe-Pro-2-chlorofuran derivative (13l)
Resolution1.79 Å
Binding residue
(original residue number in PDB)		F34 T74 R75 Y76 K81 I82
Binding residue
(residue number reindexed from 1)		F19 T69 R70 Y71 K77 I78
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E202 G203 D204 S205 G206
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:6zgo, PDBe:6zgo, PDBj:6zgo
PDBsum6zgo
PubMed
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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